Health Condition 1: 8- Other Procedures
Conditions
Interventions
Intervention1: Subarachnoid block with hyperbaric bupivacaine in infra umbilical surgeries alongwith preoperative oral pregabalin.: Tablet pregabalin(150 mg), will be given to the patients with a sip
Sponsors
Office of PrincipalMidnapore Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Cases with ASA grade I and II. Age group between 18-65 years. Cases with height between 150-180cms. Patients willing to give written consent. Patients with body weight 50-70kg. Cases undergoing infra-umbilical surgeries performed under subarachnoid block.
Exclusion criteria
Exclusion criteria: Cases which has contraindication to spinal anaesthesia. Cases with ASA grade III and above. Patients undergoing upper abdominal surgeries. Pregnant and lactating patients. Patients with psychiatric disorders. Cases with history of allergy or hypersensitivity to study drugs. Cases with any neuropathy or neurological disorder. Patients with any ongoing therapies with sustained release opioids. Any cardio-respiratory disorder. Any hepato-renal disorders. Immuno-compromised patients. Diabetic patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect preoperative administration of oral pregabalin or clonidine will reduce the incidence of immediate postoperative pain in patients undergoing surgery in comparison to the placebo groupTimepoint: For VAS score- baseline(immediate postoperative),1hour,2 hour,4 hour,6 hour,8 hour,12 hour,16 hour,20 hour,24 hour. For time to first rescue analgesic-immediate post operative period till complain of significant pain. For total dose of rescue analgesic- immediate post operative period till 24 hour. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters like mean arterial pressure heart rate.Evaluate sensory and motor block parameters after subarachnoid block. Determine sedation. Record side effects and sedation score in all groups. Timepoint: Intraoperative hemodynamic parameters- baseline,then every 5 minute till operation lasts. Motor and sensory block characteristics- immediately after sub arachnoid blocke, at 5 minute interval till the regression of sensory and motor block. Side effects and sedation scores - baseline,at interval of 1 hour till end of 24 hour. | — |
Countries
India
Contacts
Public ContactDr Prosenjit Mukherjee
IPGMER
Outcome results
None listed