Health Condition 1: A753- Typhus fever due to Rickettsia tsutsugamushi
Conditions
Interventions
Intervention1: DOXYCYCLINE: Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ri
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: Patients within the age defined criteria who presented with severe scrub typhus (reduced level of consciousness, clinical jaundice, shock, vomiting severe enough to disallow the use of oral medications, clinical or radiological evidence of lung involvement, clinical evidence of meningitis/encephalitis or the need of a lumbar puncture, any other syndrome that in the opinion of the admitting doctor constitutes severe scrub typhus (reason stated by the treating physician), ability to stay in the hospital for the duration of treatment (duration of 7 days) and a high likelihood of completing at least 4 weeks follow up, negative pregnancy test for all women of childbearing age-as from history and/or negative urinary pregnancy test
Exclusion criteria
Exclusion criteria: participants who are contraindicated to doxycycline and azithromycin or both, patients who had taken chloramphenicol, tetracycline, or ciprofloxacin during the previous 48 hours, pregnancy or breastfeeding, long term use of immunosuppressant (eg. steroids, chemotherapy, TNF-inhibitors) and use of HAART for HIV patients, have a non-infectious cause of pulmonary infiltrates, have or be at risk for major cardiac events or dysfunction, received within 7 days before enrollment of class Ia or Class III anti-arrhythmic medication, end-stage renal disease (stage 5)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome: To compare the fever clearance time between patients in specific treatment groups, to compare the rate of resolution of laboratory parameters towards normalization between the treatment groups Timepoint: 48 to 72 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 26. Secondary Outcome:Treatment failure rates among patients with various organ specific involvements as a complication of scrub typhus, any other presentations unaccounted previously. Timepoint: 48 to 72 hours | — |
Countries
India
Contacts
Public ContactDr Prasan Kumar Panda
Aiims, Rishikesh
Outcome results
None listed