Effect of addition of White blood cell transfusion in decreasing death rate in cancer drug induced infection in children.

Effect of addition of irradiated buffy coat derived granulocyte transfusion to the standard of care in children with post chemotherapy high risk febrile neutropenia in decreasing mortality-An open label randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/10/028204

Enrollment

100

Registered

2020-10-01

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D499- Neoplasm of unspecified behavior of unspecified site

Interventions

Intervention1: intervention arm will recieve granulocyte transfusion in addition to standard of care for high risk febrile neutropenia. Control arm will receive standard of care for high risk febrile

Eligibility

Inclusion criteria

Inclusion criteria: 1)Children aged less than or equal to 18 years with malignancy and chemotherapy induced high risk febrile neutropenia 2) Written informed consent

Exclusion criteria

Exclusion criteria: 1) Unavailability of group specific granulocyte in blood bank 2) Children on palliative care 3) Patients undergoing Hematopoietic stem cell transplant 4) Children on recovering phase of illness

Design outcomes

Primary

Measure	Time frame
MortalityTimepoint: 28 days from randomization	—

Secondary

Measure	Time frame
1)Duration of hospital stay 2) Use of antibiotics in antibiotic days 3)Day of defervescence 4)Occurrence of adverse eventsTimepoint: At time of discharge/ Expiry	—

Countries

India

Contacts

Public ContactMohanaraj R

AIIMS, Newdelhi

adivick@gmail.com7838379837

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026