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Understanding the scar tissue after burn injury

Investigating the role of WNT signalling pathway in fibroblasts derived from hypertrophic scar post thermal injury - WNT project

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/028120
Enrollment
20
Registered
2020-09-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T311- Burns involving 10-19% of body surface

Interventions

None listed

Sponsors

Symbiosis International University
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with thermal burn injury leading to formation of hypertrophic scars around major joints

Exclusion criteria

Exclusion criteria: The patients within three months of burn injury will be excluded

Design outcomes

Primary

MeasureTime frame
The expected outcome of this study would be better understanding of how WNT signaling pathway functions at the molecular level in human post burn hypertrophic scar fibroblasts Timepoint: The hypertrophic scar derived fibroblasts would be treated with WNT inhibitors/activator for 7 days and then RNA and proteins would be harvested for molecular analysis—

Secondary

MeasureTime frame
NATimepoint: NA—

Countries

India

Contacts

Public ContactMugdha Pradhan

Symbiosis Centre for Stem Cell Research

prasad.pethe@ssbs.edu.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026