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Role of Genetic components in development of Dental caries and developmental defects like Molar Incisor Hypomineralisation

Quantification of Human MMP20 as a biomarker in Children with or without Caries experience and Molar incisor hypomineralisation (MIH) â?? An Enzyme-linked immunosorbent assay - MMP 20, ELISA

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/028114
Enrollment
400
Registered
2020-09-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

None listed

Sponsors

Rajiv Gandhi university of Health Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The Inclusion criteria for the study are a)Group 1 â?? Caries free children not showing MIH conditions Caries experience; b) Group 2 Children with mixed dentition having normal occlusal relationship Children with presence of one or more decayed (Non cavitated/cavitated/white chalky lesions) missing due to caries or filled tooth surfaces. MIH European academy of Pediatric dentistry criterion is used to record MIH2 with the showing demarcated opacities, showing from white to brownish colour and grouped as follows; c) Group 3 - teeth with mild MIH with or withour posteruptive breakdown with no caries lesions. d) Group 4 â??teeth with severe MIH with posteruptive breakdown of enamel/ dentin with caries lesion.

Exclusion criteria

Exclusion criteria: Exclusion criteria Children on medication for chronic diseases in the last three months Children with special health care needs Children with acute foci of infection in the oral cavity

Design outcomes

Primary

MeasureTime frame
To determine the association of MMP20 in MIH conditions and as a biomarker for dental caries experience particular for dental caries in Indian population. It also contributes to understand the role of MMP20 as biomarker in Indian population as they have known to show ethnic, and geographic specificity.Timepoint: group 1 - saliva samples are collected in first 3 months interval. group 2 - sliva samples are collected during first 6 months interval group 3 - saliva samples are collected in the first 9 months interval group 4 saliva samples are collected i the first 12 months interval and are subjected to Elisa for analysis of MMP20—

Secondary

MeasureTime frame
To use it as an educative modelTimepoint: two years—

Countries

India

Contacts

Public ContactDr Jaya A R

Rajarajeswari Dental College and Hospital

jaya.vrushabh@gmail.com09880038038

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026