Health Condition 1: C220- Liver cell carcinoma Health Condition 2: C00-D49- Neoplasms
Conditions
Interventions
Intervention1: sodium bicarbonate: Before doing standard TACE, In each tumor feeding artery, about 25â??ml bicarbonate would be injected into tumor feeding artery. Maximum of 3 arteries will be treate
Sponsors
TATA MEDICAL CENTER
Eligibility
Inclusion criteria
Inclusion criteria: - All patients with hepatocellular carcinoma who are candidates for trans-arterial chemoembolization - Patients who consent for the study - A diagnosis of HCC based on EASL or histological evidence, - Barcelona Clinic Liver Cancer (BCLC) stage A, B , - Child-pugh A , - Hypervascular lesion as evaluated by triphasic MRI or CT and digital subtraction angiography (DSA).
Exclusion criteria
Exclusion criteria: - BCLC -C , D, - Child pugh B,C - Evidence of combined A-V shunt. - Main portal vein thrombus - General contraindication for TACE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Safety of adding bicarbonate along with TACETimepoint: 1 MONTH, 3 MONTH, 6 MONTH | — |
Secondary
| Measure | Time frame |
|---|---|
| - Overall survival post TACE on an intention to treat analysis - Progression free survival post TACE - Remaining viable tumor post TACE at follow-up scan - Survival stratified by stage Timepoint: 3 YEARS | — |
Countries
India
Contacts
Public ContactDAYANANDA LINGEGOWDA
TATA MEDICAL CENTER
Outcome results
None listed