FindTrial
Sign In

Comparison between two drugs etomidate and propofol used to provide unconsciousness during general anaesthesia in elderly population

Comparison between etomidate and propofol for induction of general anaesthesia in elderly

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/028003
Enrollment
78
Registered
2020-09-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Etomidate: Etomidate is administered IV for induction of general anaesthesia in elderly Dose: Graded doses (2ml every 10 seconds) until no response to mild prodding and shaking at a con

Sponsors

Dr Avanish Bhandary
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Individuals aged 60 years and above undergoing elective non cardiac surgeries requiring general anaesthesia with endotracheal intubation 2. American society of anaesthesiologist physical status 1, 2 and 3

Exclusion criteria

Exclusion criteria: 1. Known allergy to propofol/etomidate 2. Anticipated difficult airway 3. Known primary and secondary adrenal insufficiency 4. Individuals on steroid medications in the past 6 months 5. History of seizure disorder 6. Patient refusal

Design outcomes

Primary

MeasureTime frame
1.To compare change in SBP, DBP, HR and MAP following induction of anaesthesia in elderly with propofol and etomidate, up to 10 mins post intubation. 2. To find a better inducing agent with respect to haemodynamic stability in elderlyTimepoint: Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, SpOâ??, respiratory rate will be recorded a baseline value after connecting the monitors, after induction, just before and after laryngoscopy and intubation, at 1, 3, 5, 10 minutes post intubation.—

Secondary

MeasureTime frame
To determine the proportion of undesired effects of propofol and etomidate perioperatively such as pain on injection and myoclonus. Timepoint: a) Pain during injection will also be noted using 3 points graded scale 0 â?? No pain 1 â?? Slight pain 2 â?? Moderate pain 3 â?? Severe pain b) Myoclonic movements will be observed at least for 3 minutes after giving the drug and graded as 0- No Myoclonic movements 1- Mild myoclonus 2- Moderate myoclonus 3- Severe myoclonus—

Countries

India

Contacts

Public ContactPrarthana M Raj

K S Hegde Medical Academy

avanishbhandary@gmail.com9845679949

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026