Health Condition 1: K77- Liver disorders in diseases classified elsewhere
Conditions
Interventions
Intervention1: EUS-Guided liver biopsy: It will be done as per the Institution’s EUS-LB protocol using wet suction technique. Patients undergoing EUS-LB will receive moderate sedation using midazolam
Sponsors
Jayanta Samanta
Radhika Chavan
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients referred for liver biopsy for any indication. 2. Informed consent obtained from the patient/parent 3. = 12 years old 4. Ability to undergo conscious sedation for EUS procedure
Exclusion criteria
Exclusion criteria: 1. Age 2. Unable to obtain informed consent from the patient/parent 3. Medically unfit for sedation 4. Pregnant patients 5. Presence of a mass lesion in the liver requiring biopsy visualized on cross-sectional imaging 6. Irreversible coagulopathy as determined by platelet count 1.5 7. Unable to stop anticoagulation or anti-platelet therapy for 5 days prior to the procedure 8. Hemophilia 9. Presence of an alternative etiology for elevated liver tests seen during the liver biopsy, e.g. biliary obstruction during EUS examination 10. Suspected or proven malignant liver disease. 11. severe cardiovascular and pulmonary diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare EUS-liver biopsy and percutaneous liver biopsy for the ability to acquire adequate tissue sampleTimepoint: At the end of the biopsy procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rates of specimen adequacy 2. Post processing maximum specimen length 3. Portal tracts: The total number of complete portal tracts obtained. 4. The total length of time for the procedure will be documented in minutes. 5. Rate of adverse events 6. Assessment of pain scores 7. Pain medication requirement: use of narcotics/analgesics in both the arms, post procedure. Timepoint: At the end of the biopsy procedure | — |
Countries
India
Contacts
Public ContactJayanta Samanta
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed