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Comparison of efficacy of patients own blood pleurodesis versus doxycycline pleurodesis in the management of persistent air leak in patients with secondary spontaneous pneumothorax

Comparison of efficacy of autologous blood patch pleurodesis versus doxycycline pleurodesis in the management of persistent air leak in patients with secondary spontaneous pneumothorax - A randomised control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/09/027984
Enrollment
38
Registered
2020-09-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J938- Other pneumothorax and air leak

Interventions

Intervention1: Autologous blood patch pleurodesis: Autologous blood patch pleurodesis. Using an aseptic technique 50 ml of venous blood preferably from the cubital vein will be withdrawn using 50 ml
Under strict aseptic precautions 20 ml of 1%lignocaine ( after checking sensitivity)will be instilled in order to reduce the pain perception.After 15 minutes Doxycycline 500 mg will be mixed with 50

Sponsors

No sponsor
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Age >18 2 Patients with secondary spontaneous pneumothoraxand Persistent Air leak grade 1- 2

Exclusion criteria

Exclusion criteria: 1 Previous history of pleurodesis 2 Traumatic spontaneous pneumothorax 3 Patients with underlying haematological disorders- coagulopathies 4 Patients with hypotension and other cardiopulmonary disease 5Known case of allergy to doxycycline .

Design outcomes

Primary

MeasureTime frame
Autologous blood patch pleurodesis is a cheap,simple, well tolerated procedure with minimal side effects . If efficacy of Autologous blood patch pleurodesis is proven to be better or equal to theDoxycycline pleurodesis, it can be used as the pleurodising agent of choice in secondary spontaneous pneumothorax.Timepoint: Every day till 7th day after procedure—

Secondary

MeasureTime frame
The rate of complications after blood patch pleurodesis and doxycycline pleurodesis.Timepoint: Every day till 7th day after procedure—

Countries

India

Contacts

Public ContactDr Naren chandra V

Jawaharlal Institute of Postgraduate Medical Education and Research

vishnu1429@yahoo.com9894365158

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026