Use of tablets of Pregabalin and Clonidine to give safer general anesthesia to patients during gall bladder removal operations.

Oral Premedication with pregabalin or clonidine for hemodynamic stability during laryngoscopy and laparoscopic cholecystectomy : A comparative evaluation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/09/027926

Enrollment

Registered

2020-09-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: Pregabalin,Clonidine: Changes on Hemodynamic Parameters after oral premedication with Pregabalin OR Clonidine Acting as Group 1 OR Group 2 Pregabalin - 75mg orally to be given 60 to 75

Eligibility

Inclusion criteria

Inclusion criteria: Prior Written informed consent. Patients scheduled for Laparoscopic Cholecystectomy. Patients with ASA grade 1 and 2.

Exclusion criteria

Exclusion criteria: Patient refusal or Unco-operative patients History of chronic pain/ neuropathy. Patients with co-existing cardiac disease, asthma, severe renal or hepatic dysfunction. Anticipated difficult intubation. Hypersensitivity reaction. Psychiatric and neurological diseases.

Design outcomes

Primary

Measure	Time frame
To assess and compare the changes in heart rate, systolic, diastolic and mean systemic arterial blood pressureTimepoint: Before induction After intubation1min,5min,10min After creation of pneumoperitonium at 15min,30min,45min 10min after release of pneumoperitonium 10min after extubation	—

Secondary

Measure	Time frame
To assess and compare post operative pain. To assess the intra operative and post operative analgesic requirement. To evaluate and compare post operative nausea and vomiting. Timepoint: RSS at whendrug is given,1hour,2hours,4hours VAS at 30min after extubation,60min after extubation,4hours after extubation, 8hours after extubation,12hours after extubation POST OP NAUSEA/VOMITTING yes 0r no RESCUE ANALGESIA yes 0r no	—

Measure

Time frame

To assess and compare post operative pain. To assess the intra operative and post operative analgesic requirement. To evaluate and compare post operative nausea and vomiting. Timepoint: RSS at whendrug is given,1hour,2hours,4hours VAS at 30min after extubation,60min after extubation,4hours after extubation, 8hours after extubation,12hours after extubation POST OP NAUSEA/VOMITTING yes 0r no RESCUE ANALGESIA yes 0r no

—

Countries

India

Contacts

Public ContactAditya Kumar

Department Of Anesthesiology and Critical Care , JNMCH, AMU

syedkamranhabib@gmail.com9897172780

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026