Health Condition 1: F20-F29- Schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders
Conditions
Interventions
Intervention1: KETOFOL: Randomized Crossover design, patients will undergo 8 ECT sessions, in first 4 sessions, each patient will receive either of the drug (according to randomization), next 4 sessio
Sponsors
All India Institute of Medical Sciences Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing Electroconvulsive therapy for schizophrenia with ASA grading 1,2 . 2. Patients undergoing electroconvulsive therapy for treatment resistant schizophrenia i.e. nonresponse to at least two trials of antipsychotic medication of adequate dose and duration. 3. Age 18 to 70 years and of either sex.
Exclusion criteria
Exclusion criteria: 1. Patients with known allergy to study drugs. 2. Egg allergy 3. Patients/relatives who will deny for consent of the procedure. 4. Pregnant and lactating females. 5. Patients with uncontrolled hypertension, history of myocardial infarction, increased intracranial pressure and patients with ASA grading 3 or more.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The stimulus dose of charge delivered for seizure inductionTimepoint: At each ECT session | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Motor seizure duration. 2. Time for recovery after ECT. 3. The hemodynamic parameters before induction, after induction, 1 min., 2 min, 5 min. & 10 min. after stimulus. 4. Effect on cognition by MOCA score after 4 sessions of ECT. Timepoint: 1. Motor seizure duration. 2. Time for recovery after ECT. 3. The hemodynamic parameters before induction, after induction, 1 min., 2 min, 5 min. & 10 min. after stimulus. 4. Effect on cognition by MOCA score after 4 sessions of ECT. | — |
Countries
India
Contacts
Public ContactJaydeep Sanghani
Aiims Bhubaneswar
Outcome results
None listed