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Role of Diazepam, Lorazepam and Oxazepam in Alcohol dependence

Comparative efficacy of Diazepam, lorazepam and Oxazepam in the treatment of alcohol withdrawal syndrome

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/09/027867
Enrollment
60
Registered
2020-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: Diazepam: Tab Diazepam orally in the range of 5-30mg in divided doses, depending upon SADQ and CIWA-Ar scores for a period of 2 weeks or till the patient in ward for detoxification Inte

Sponsors

GMCH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with Alcohol Dependence Syndrome as per ICD-10 2. Male patients in the age range of 18-60 years 3. Willing to get admitted as independent patient

Exclusion criteria

Exclusion criteria: 1. Dependence on other substances except nicotine and caffeine 2. Significant liver impairment ( liver enzymes increased more than 3 times) and unstable medical disorder 3. History of complicated withdrawals in the past (DT, Withdrawal Seizures etc) 4. History of hypersensitivity to diazepam, lorazepam and oxazepam 5. Active psychotic patient 6. Acutely suicidal patient 7. Intoxicated patient

Design outcomes

Primary

MeasureTime frame
efficacy in controlling alcohol withdrawals on CIWA-Ar scoresTimepoint: daily administration of CIWA-Ar to assess the severity of withdrwals till the patient in ward or up to 15 days—

Secondary

MeasureTime frame
Reduction in CIWA-Ar scores Duration of stay in hospitalTimepoint: 10-15 days—

Countries

India

Contacts

Public ContactAjeet Sidana

GMCH, Chandigarh

ajeetsidana@hotmail.com09646121614

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026