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To study the improvement in hearing by using combination therapy ( oral steroids and platelet rich plasma) in sudden hearing loss

"Therapeutic Efficacy of the Combination of Intratympanic Injection of Platelet Rich Plasma (IT PRP) and Oral Steroids for Adult Onset Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) at a Tertiary Care Centre- A Randomised Controlled Trial"

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/09/027804
Enrollment
30
Registered
2020-09-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H838- Other specified diseases of innerear

Interventions

Intervention1: group B intervention group(Combination therapy- oral steroids and intratympanic platelet rich plasma): patients in combination therapy will receive same steroid regime as well as 2 dose

Sponsors

Uttrakhand state council for science and technologyUCOST
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Unexplained sudden sensorineural hearing loss, which is defined as a sensorineural hearing loss of at least 30 dB at 3 contiguous frequencies over a period of 2. Normal tympanic membrane on otoendoscopy 3. No history of ear disease in the affected ear 4. Age 18-50 years

Exclusion criteria

Exclusion criteria: 1. Patients with conductive HL, mixed HL or other causes of sensori-neural hearing loss. 2. Patients with perforated ear drum 3. Age 50 yrs 4. Operated ear 5. Individuals with a previous history of ear discharge

Design outcomes

Primary

MeasureTime frame
Hearing gain reporting as per American Association of Otorhinolaryngology-Head Neck Surgery guidelines with PTA at 0.5-,1-,2- and 3KHz and recovery outcome using modified Siegleâ??s criteria.Timepoint: follow up at 2nd and 4th week—

Secondary

MeasureTime frame
Improvement in speech discrimination score (SDS) Reduction in tinnitus perception in both groups based on Tinnitus Functional Index and Tinnitogram.Timepoint: follow up at 2nd and 4th week—

Countries

India

Contacts

Public ContactDr Madhu Priya

AIIMS Rishikesh

drpriyamadhu@gmail.com09751003933

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026