Health Condition 1: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung
Conditions
Interventions
Intervention1: Resveratrol copper plus WBRT: WBRT to a dose of 30 Gy in 10 fractions over 2 weeks along with Resveratrol Copper 4 times a day starting 2 days prior to WBRT and till 2 days after comple
Sponsors
Jai Prakash Agarwal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years 2. Patients with ECOG performance status of 0-2 3. Patients with histologic or cytologic diagnosis of NSCLC 4. Patients with radiologically measurable brain metastases 5. Patients planned for systemic therapy 6. Patients willing for written informed consent and must be willing to comply with the specified follow up schedule 7. Signed written informed consent
Exclusion criteria
Exclusion criteria: 1)Patients with leptomeningeal dissemination without measurable parenchymal brain metastases 2)Patients with brain metastases in the brain stem 3)Patients with prior history of radiation therapy to brain 4)Pregnant or lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the intracranial progression free survivalTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)To determine overall survival 2)To compare ORR of brain metastases 3)To compare treatment related toxicity 4)To determine the various prognostic factors for iPFS and OS 5)To evaluate patient reported outcomes Timepoint: at 3, 6 and 12 months | — |
Countries
India
Contacts
Public ContactJai Prakash Agarwal
Tata Memorial Hospital
Outcome results
None listed