Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Drug Oral AMisulpride: Intervention group: Oral Amisulpride 25 mg
Control: Placebo
(Drug/Placebo to be given 2 hours before surgery)
Sponsors
Department of Anesthesiology SGPGIMS Lucknow
Eligibility
Inclusion criteria
Inclusion criteria: Adult patient belonging to ASA I-II, 18 year to 60 years of either sex scheduled for craniotomy for supra- tentorial tumors requiring undergoing general anaesthesia will be included in the study.
Exclusion criteria
Exclusion criteria: Patients with history of nausea or vomiting 24 hours before surgery, drug or alcohol abusers, pregnant or lactating women, recipients of chemotherapy or radiation therapy during the previous 7 days, renal insufficiency, mental disorder or unconscious before the surgery who cannot normally communicate, menstruating phase of the menstrual cycle, history of epilepsy and still taking an anti-epileptic medicine, undergoing ventricle or brainstem surgery will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be incidence of nausea and/or vomiting or retching.Timepoint: 24 hour postoperative | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome will be severity of nausea, number of times rescue medication used, postoperative pain, postoperative analgesia and incidences of other critical incidences within 24 hours postoperatively. Timepoint: Five interval. 1, 2, 4, 8, and 24 hours | — |
Countries
India
Contacts
Public ContactANUBHA GUPTA
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow
Outcome results
None listed