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COMPARISON BETWEEN DEXMEDETOMIDINE AND MAGNESIUM SULPHATE ON STRESS RESPONSE IN LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA.

COMPARISON OF DEXMEDETOMIDINE AND MAGNESIUM SULPHATE ON STRESS RESPONSE IN ADULT PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA.

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/09/027772
Enrollment
60
Registered
2020-09-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E898- Other postprocedural endocrine andmetabolic complications and disorders

Interventions

Intervention1: Dexmedetomidine: Patient will be brought to the operation theatre, dexmedetomidine 1 µg/kg (2 ml diluted in 48 ml normal saline to make total 50 ml) will be given over 15 minutes thro

Sponsors

ABVIMS and Dr RML Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I patients posted for elective laparoscopic cholecystectomy under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Hypermagnesaemia. 2. A known allergy to magnesium sulphate. 3. Any degree of heart block 4. Hypertensive or diabetic patients. 5. Acute cholecystitis. 6. Hemodynamically unstable patients 7. Pregnancy 8. BMI > 30 kg/m2

Design outcomes

Primary

MeasureTime frame
Biochemical markers of stress response (CORTISOL, TSH, INSULIN, TNF alpha, CRP and BLOOD SUGAR)Timepoint: 1) baseline sample at 8 AM 2) intra operative- 20 minutes after pneumoperitoneum 3) 4 hours after reversal of anaesthesia 4) 24 hours after reversal of anaesthesia.—

Secondary

MeasureTime frame
Hemodynamic response to pneumoperitoneum (HR, MAP, RR, SpO2)Timepoint: Preoperative, 1 minute, 5 minutes and 20 minutes after creating pneumoperitoneum.—

Countries

India

Contacts

Public ContactDr Shivam Jaisawal

ABVIMS and Dr. RML Hospital

nagpalvijaykumar@gmail.com9968304240

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026