Comparing the effects of two different ventilator settings in patients who are posted for planned surgeries in lying on back position under general anesthesia.

To compare the effects of ventilator setting of 7 ml/kg tidal volume, without PEEP and PEEP of 10 cm H2O on intraoperative ventilation and oxygenation indices in patient undergoing elective surgeries in supine position. A Prospective double blinded randomized Control Trial.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/09/027768

Enrollment

120

Registered

2020-09-11

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z408- Encounter for other prophylactic surgery

Interventions

Intervention1: 10 cm H2O PEEP: Subjects will receive 7 ml/ kg tidal volume with 10 cm H2O PEEP in elective surgeries under GA in supine position. Control Intervention1: without PEEP: Subjects will re

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2, Age: 19-65 years, BMI : 18-35, Elective surgery under GA in supine position.

Exclusion criteria

Exclusion criteria: ASA 3 and 4, Age : 65yrs, Emergency surgeries, BMI > 35, Surgeries not less than 1 hours, History of COPD, Asthma, chronic smoking.

Design outcomes

Primary

Measure	Time frame
Primary Outcome/s: To compare the oxygenation indices such as PaCo2, PaO2, PaO2/FiO2 ratio, pH, lactates. Timepoint: one hour from intubation	—

Secondary

Measure	Time frame
Secondary Outcome: To compare the adequacy of ventilation based on ETCO2 changes, peak airway pressure and hemodynamic changes such as heart rate and blood pressure. Timepoint: one hour from intubation	—

Countries

India

Contacts

Public ContactMadhumitha PS

Christian Medical College

sajanpg@cmcvellore.ac.in8098118456

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026