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Comparing the effect of Dexmedetomidine and ketamine on cognitive function after surgery

Effect of dexmedetomidine versus subanaesthetic ketamine infusions on post-operative cognitive function in patients undergoing major abdominal surgeries: A randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/09/027767
Enrollment
90
Registered
2020-09-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system

Interventions

Intervention1: dexmedetomidine, Subanaesthetic Ketamine: Group A receives dexmedetomidine infusion and Group B receives subanaesthetic ketamine infusion to be started at the beginning of the surgery a

Sponsors

All India Institute of Medical Sciences Bhubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II patients undergoing major abdominal surgery 2. Age 18 to 80 years

Exclusion criteria

Exclusion criteria: 1. Patients with previous history of Schizophrenia, Dementia or Parkinsonism 2. Patients taking any kind of psychiatric treatment. 3. Patients in sepsis (either fever, raised TLC, known source of infection). 4. Patients already on ventilator. 5. Patients who are not extubated within 2 hours after surgery. 6. Known contraindications to either of the drugs. 7. Pregnant women.

Design outcomes

Primary

MeasureTime frame
to compare MMSE score between 3 groupsTimepoint: 6 hours post-extubation—

Secondary

MeasureTime frame
1. Minimum alveolar concentration(MAC) required to achieve targeted Bispectral Index(50-60). 2. Time to extubate( from time of initiation of skin closure to tracheal extubation). 3. Post-operative pain scores (every 2 hourly for 6 hours after extubation). 4. The effect on hemodynamic parameters of dexmedetomidine and subanaesthetic ketamine infusion Timepoint: intra operatively every hourly post operatively hourly till 6 hours after extubation—

Countries

India

Contacts

Public ContactKaushik D S

All India Institute of Medical Sciences Bhubaneswar

anaes_prasanta@aiimsbhubaneswar.edu.in9312677007

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026