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Understanding the role of inflammation on the occurrence of cognitive impairment (memory decline) related to cancer chemotherapy in lymphoma patients

An observational study to explore the involvement of inflammation and depression on the occurrence of chemotherapy-related cognitive impairment in lymphoma patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/027732
Enrollment
83
Registered
2020-09-10
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C858- Other specified types of non-Hodgkin lymphoma

Interventions

None listed

Sponsors

Jamia Hamdard
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient must have histologically and cytologically confirmed lymphoma; patient receiving chemotherapy for the treatment of lymphoma; capable of giving informed consent; willing to participate in the study.

Exclusion criteria

Exclusion criteria: Patient below 18 years of age, history of cognitive impairment and Alzheimerââ?¬•s disease; history of depression; history of head injury; patient with history of any type of cancer; any cancer patient with brain involvement; ongoing psychotropic medications; history of schizophrenia or any other neuropsychiatric disorders; habit of any substance of abuse; using any concurrent medication for any neuropsychiatric disorder; using anti-inflammatory drugs; incompetent for interview; not willing to participate and give consent for the study.

Design outcomes

Primary

MeasureTime frame
Possible correlation of different inflammatory mediators with chemotherapy-related cognitive impairment Timepoint: a)Before 1st cycle of chemotherapy (at baseline) b)Before 4th cycle of chemotherapy (T2) c)After 6th cycle of chemotherapy (T3)

Secondary

MeasureTime frame
Change in the quality of life of lymphoma patients after receiving chemotherapyTimepoint: At the end of 6th cycle of chemotherapy;Dysregulation of serum levels of peripheral inflammatory markers after cycles of chemotherapyTimepoint: After six cycles of chemotherapy;Probable occurrence of cognitive impairment after receiving consecutive cycles of chemotherapyTimepoint: AFter 6 cycles of chemotherapy;Probable occurrence of depression after receiving consecutive cycles of chemotherapyTimepoint: After 6 cycles of chemotherapy

Countries

India

Contacts

Public ContactDr Nidhi Agarwal

Rajiv Gandhi Cancer Institute and Research Centre

bhurani@gmail.com9971500861

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026