Comparision of two drugs named Phenylephrine and Norepinephrine to decrease the occurance of low blood pressure after spinal anaesthesia in cesarean deliveries.

Comparative study of Phenylephrine infusion and Norepinephrine infusion for prevention and treatment of spinal anaesthesia induced hypotension in elective and emergency cesarean deliveries.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/09/027704

Enrollment

Registered

2020-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O94- Sequelae of complication of pregnancy, childbirth, and the puerperium

Interventions

Intervention1: injection Norepinephrine intravenous infusion: at the rate of 2.5 micrigram/minute, hypotension will be intervened by bolus dose of 2.5 micrograms Control Intervention1: injection Pheny

Eligibility

Inclusion criteria

Inclusion criteria: All pregnant patients undergoing elective and emergency cesarian who have been given consent for American Society of Anesthesiologists grade 2 and 3 and do not have contraindication to any of the drugs to be studied.

Exclusion criteria

Exclusion criteria: 1)Pregnant females with gestational age of less than 36 weeks 2)Known co-morbidities such as severe pregnancy induced hypertension, Diabetes Mellitus, cardiac diseases, epilepsy, eclampsia 3)Patient refusing for spinal anaesthesia 4)contraindication for spinal anaesthesia

Design outcomes

Primary

Measure	Time frame
1)Systolic blood pressure 2)Diastolic blood pressure 3)Mean arterial pressure 4)Heart rateTimepoint: different hemodynaemic and vital parameters at different point of time after spinal anaesthesia 1)baseline 2)at 2 minutes 3)at 4 minutes 4)at 6 minutes 5)at 8 minutes 6)at 10 minutes 7)at 15 minutes 8)at 20 minutes 10)at 30 minutes 11)at 45 minutes 12)at 60 minutes	—

Secondary

Measure	Time frame
APGAR scoreTimepoint: at 1 minute and 5 minutes;occurance of materal nausea and vomitingTimepoint: at any given time	—

Countries

India

Contacts

Public ContactDr Payal Berawala

Pramukh Swami Medical College and Shree Krishna Hospital and Research Center

madhavic@charutarhealth.org9427084963

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026