Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention1: Two or more arterial grafts: Left ITA and additional one or more arterial grafts-
RITA or RA and additional saphenous vein graft/s if require
Control Intervention1: Single arterial gra
Sponsors
Indian Council of Medical Research ICMR
Dr Kunal Sarkar
Dr Lokeswara Rao Sajja
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female aged between 18 to 70 yrs 2. Patients with significant triple vessel disease or LMCA stenosis 3. Requiring isolated non emergent CABG 4. Receiving oral anti diabetic agents or insulin (HbA1c less than or equal 10%) 5. Left ventricular ejection fraction more than or equal 35 % 6. Serum creatinine less than or equal 1.5mg/dL 7. Able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Male or female aged less than 18 and more than 70 years 2. HbA1c more than 10% 3. Serum creatinine more than 1.5% mg/dL 4. Left ventricular ejection fraction less than 35 % 5. Patients undergoing combined procedures 6. Emergent/urgent CABG 7. Patients undergoing redo-CABG 8. Previous cardiac surgery 9. Preoperative severe end-organ dysfunction (on maintenance dialysis, liver failure respiratory failure), cancer or any co-morbidity that reduce life expectancy to less than 5 years. 10. Unsuitable saphenous vein, radial artery and internal thoracic arteries 11. Symptomatic carotid artery stenosis (morethan 70%) 12. COVID-19 positive 13. Not able to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite of death from any cause, any stroke, and non fatal myocardial infarction and/or repeat revascularization at 5 yearsTimepoint: 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Graft patency and clinical outcomes at one year Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactDr Lokeswara Rao Sajja
Star Hospitals
Outcome results
None listed