Health Condition 1: N08- Glomerular disorders in diseases classified elsewhere
Conditions
Interventions
Intervention1: Canagliflozin arm: To receive canagliflozin 100 mg per day. Patients diagnosed as glomerulonephritis on the basis of renal biopsy and having proteinuria 1 gm/day
Should have e GFR 25
Sponsors
COMMAND HOSPITAL AIR FORCE BANGALORE
Eligibility
Inclusion criteria
Inclusion criteria: Patient in age group 18 to 75 years, registered in Nephrology OPD and was diagnosed as glomerulonephritis on the basis of renal biopsy and having proteinuria > 1 gm/day Should have e GFR > 25 ml/min/1.73 m2 The patient should be on a stable dose of an ACEi or ARB/immunosuppression for at least 4 weeks prior to randomization
Exclusion criteria
Exclusion criteria: Patient detected to be diabetic prior to enrolment or during the study Patient lost to follow up during the study period Patient whose baseline and follow up laboratory investigations, 24 hr urine protein, detailed renal biopsy report not available
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in 24 hr proteinuria with canagliflozin for six weeks relative to no canagliflozin in patients with non diabetic kidney disease and proteinuria 1 gm/day on standard of care treatment(ACEI/ARB and immunosuppression if indicated)Timepoint: Change in 24 hr proteinuria with canagliflozin for six weeks relative to no canagliflozin in patients with non diabetic kidney disease and proteinuria 1 gm/day on standard of care treatment(ACEI/ARB and immunosuppression if indicated) | — |
Secondary
| Measure | Time frame |
|---|---|
| i. Effect of canagliflozin 100 mg/day compared to no canagliflozin on eGFR using EPI equation ii. Compare the effect of canagliflozin 100 mg/day on proteinuria of different aetiologies Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactVijoy Kumar Jha
COMMAND HOSPITAL AIR FORCE BANGALORE
Outcome results
None listed