Health Condition 1: E112- Type 2 diabetes mellitus with kidney complications
Conditions
Interventions
Intervention1: Exercise based rehabilitation: Individuals will receive exercise based rehabilitation along with standard nephrological care, diabetic education and diet-nutrition plan.
Control Interve
Sponsors
Department of Science and Technology
Eligibility
Inclusion criteria
Inclusion criteria: Type 2 diabetes mellitus individuals with nephropathy having estimated glomerular filtration rate between 15-90 ml/min/1.73m2 or with persistent proteinuria
Exclusion criteria
Exclusion criteria: Individuals with the following will be excluded such as Diagnosed with Type 1 diabetes mellitus, stage 5 chronic kidney disease on dialysis or renal transplant, undergone any recent cardiovascular event/procedure in the last 6 months, severe anemia having hemoglobin levels less than 7g/dL, resting systolic blood pressure more than 160 mmHg &/or resting diastolic blood pressure more than 110 mmHg, absolute contraindications to exercise testing and prescription (based on ACSM), or presently enrolled/engaged in any structured supervised exercise program or involved in vigorous activities, pregnant women and those receiving radiation or chemotherapy, any neuromuscular condition restricting exercise testing and prescription, a peripheral arterial disease with ankle-brachial index(ABI) value less than 0.9, newly developed diabetic foot ulcers or amputation of the lower limb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Renal function-Blood urea nitrogen,Micro/Macro albuminuria,Serum creatinine,Estimated glomerular filtration rate 2)Quality of lifeTimepoint: Assessed at three time points which are baseline, 12th week and 24th week | — |
Secondary
| Measure | Time frame |
|---|---|
| 3)Fatigue 4)Functional capacity with six minute walk distance 5)Inflammatory and oxidative stress markers such as high sensitive c-reactive protein, malondialdehyde,glutathione 6)Body composition such as body weight and body mass index 7)Hemoglobin levelTimepoint: Assessed at three time points which are baseline, 12th week and 24th week | — |
Countries
India
Contacts
Public ContactDr Arun G Maiya
Manipal College of Health Professions
Outcome results
None listed