Health Condition 1: M498- Spondylopathy in diseases classified elsewhere
Conditions
Interventions
Intervention1: Nicotine patch: Nicotine patch will be administered from one day prior to surgery by the principal investigator over the non hairy area of the upper limb or shoulder every 24 hours till
Sponsors
Dr Puneet Khanna
Eligibility
Inclusion criteria
Inclusion criteria: •Posted for spinal fusion surgery or discectomy •History of active smoking (at least one cigarette per day) •ASA I and ASA II.
Exclusion criteria
Exclusion criteria: •Refusal to consent •Body mass index (BMI) > 30 kg/m2; •Any present or past history suggestive of cardiovascular diseases (excluding hypertensive patients well controlled on treatment), hepatic dysfunction or renal dysfunction •Any present or past history suggestive of acute or chronic pain or intake of any medication known to affect pain thresholds; •History of drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢To estimate the total morphine consumption in patients administered with nicotine patch ( Group A) and patients without nicotine patch (Group B) at the end of 24 hours in patients undergoing spinal fusion surgery or discectomy. â?¢To assess pain scores at rest and movement at 0, 6, 12 and 24 hours in the postoperative period. â?¢To correlate the blood nicotine levels measured a day before surgery and 24 hours after surgery with post-operative morphine consumption. Timepoint: â?¢To estimate the total morphine consumption in patients administered with nicotine patch ( Group A) and patients without nicotine patch (Group B) at the end of 24 hours in patients undergoing spinal fusion surgery or discectomy. â?¢To assess pain scores at rest and movement at 0, 6, 12 and 24 hours in the postoperative period. â?¢To correlate the blood nicotine levels measured a day before surgery and 24 hours after surgery with post-operative morphine consumption. | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢To compare the adverse effects of opioids in both the groups such as hypoxia, respiratory depression, sedation, pruritis, ileus, urinary retention, nausea and vomiting etc. â?¢To assess the adverse effects of nicotine replacement therapy such as tachycardia, arrhythmias or myocardial ischemia etc. Timepoint: 1. Side effects of morphine -24 hours after surgery 2. Side effects of nicotine - one day before surgery to 48 hours after surgery | — |
Countries
India
Contacts
Public ContactDr Puneet Khanna
All India Institute of Medical Sciences
Outcome results
None listed