Health Condition 1: F322- Major depressive disorder, singleepisode, severe without psychotic features
Conditions
Interventions
Intervention1: Oral ketamine: oral dose of 2.0â??2.5 mg/kg ketamine will be administered on day 0, day 3, day 5, day 7, day 9, day 11 and day 13
Control Intervention1: Intravenous ketamine 0.5 mg/kg:
Sponsors
Dr P N Suresh Kumar
Eligibility
Inclusion criteria
Inclusion criteria: 1 Failed 2 trial of different antidepressant class of adequate dose and duration. 2 Current depressive episode is of at least 4 weeks duration. 3 Not received ECT at least prior to enrollment.
Exclusion criteria
Exclusion criteria: 1 Other psychiatric disorders. 2 Pregnancy and lactation. 3 Concurrent major life-threatening illness like malignancy, cardiac failure, renal failure etc. 4 Alcohol and substance abuse and smokers. 5 Patients with electrocardiogram abnormality or abnormality on fundoscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in clinical ratings of depression in Hamilton Depression Rating ScaleTimepoint: Day 0,3,5,7,9,11,13 | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Montgomery Asberg Depression rating scale and Clinical Global Impression of severity and ImprovementTimepoint: Day 0,3,5,7,9,11,13 and 1 month | — |
Countries
India
Contacts
Public ContactDrPNSuresh Kumar MD DPM DNB PhD MRC Psych
IQRAA Psychiatric care and rehabilitation centre
Outcome results
None listed