Health Condition 1: K00-K95- Diseases of the digestive system
Conditions
Interventions
Intervention1: Albumin supplementation: albumin 10% infusion IV 0.5 gm/kg/ day over 4 hours.
Control Intervention1: Saline as placebo: To compare with Albumin supplementation in neonates undergoing
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. All neonates undergoing abdominal surgery(All GIT atresias, malrotation, gastroschisis, exomphalos minor, NEC, bowel perforations) 2. Gestation > 32 weeks
Exclusion criteria
Exclusion criteria: 1. Acute kidney injury ( Serum creatinine > 1.5) or oliguria (urine output 2. Ventilated neonates requiring Fio2 > 60%. 3. Congestive cardiac failure 4. CKD patients 5. Colostomy for anorectal malformations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in surgical complication rate in neonates receiving albumin infusion as compared to the placebo group.Timepoint: Discharge/ Death | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of sepsis in both the groups 2. Incidence of mortality in both the groups. 3. Comparison of biochemical parameters- Blood urea nitrogen levels , serum creatinine, Serum albumin levels (g/l), Serum prealbumin and sodium between two groups. 4. Comparison of ventilation days and inotrope requirement in both the groups. Timepoint: At discharge/ Death | — |
Countries
India
Contacts
Public ContactDr SHIVANI DOGRA
PGIMER CHANDIGARH
Outcome results
None listed