Health Condition 1: S062- Diffuse traumatic brain injury Health Condition 2: S066- Traumatic subarachnoid hemorrhage Health Condition 3: S065- Traumatic subdural hemorrhage
Conditions
Interventions
Intervention1: To evaluate effects of normal saline versus isotonic balanced crystalloid: To compare and evaluate effects of normal saline and isotonic balanced crystalloid on acid base equilibrium an
Sponsors
Department of Anaesthesiology and Critical Care
Eligibility
Inclusion criteria
Inclusion criteria: patients of either sex scheduled to undergo emergency craniotomy for traumatic brain injury will be enrolled
Exclusion criteria
Exclusion criteria: associated injuries (long bone fracture, thoracic or abdominal injuries), renal or coagulation dysfunctions, electrolyte imbalance, hemodynamic instability, pregnancy and lactation, difficult airway, comorbidities will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects on renal functions{blood urea, serum creatinine, serum electrolytes and neutrophil gelatinase-associated lipocalin(NGAL)} acid base equilibrium(pH, base excess and bicarbonate)Timepoint: baseline, induction of anaesthesia, surgical incision, bone flap removal, 1 hour after starting of surgery, closure of skin, shifting to PACU, 12 hours and 24 hours after shifting | — |
Secondary
| Measure | Time frame |
|---|---|
| serum osmolarity coagulation profile(Prothrombin time, Partial thromboplastin time, International normalised ratio)Timepoint: baseline, induction of anaesthesia, surgical incision, bone flap removal, 1 hour after starting of surgery, closure of skin, shifting to PACU, 12 hours and 24 hours after shifting | — |
Countries
India
Contacts
Public ContactAnshul Mundra
Pt. B.D. Sharma PGIMS
Outcome results
None listed