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Prospective evaluation of genetic linkage between papillary thyroid cancer and thyroiditis

GENETIC LINKAGE BETWEEN HASHIMOTOS THYROIDITIS AND PAPILLARY THYROID CARCINOMA- EXPRESSION OF RET/PTC VS BRAF MUTATION IN COEXISTENT PAPILLARY THYROID CANCER AND HASHIMOTOS THYROIDITIS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/027607
Enrollment
100
Registered
2020-09-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E063- Autoimmune thyroiditis Health Condition 2: C73- Malignant neoplasm of thyroid gland

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Indian Council of Medical Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Consecutive patients undergoing thyroidectomy for benign or malignant thyroid diseases with any of the following histopathology 1. papillary thyroid carcinoma 2. thyroiditis and 3. both papillary thyroid carcinoma and thyroiditis

Exclusion criteria

Exclusion criteria: Patients with the following histopathology, namely Medullary thyroid carcinoma, Anaplastic thyroid carcinoma, Follicular thyroid carcinoma and benign thyroid histology other than thyroiditis

Design outcomes

Primary

MeasureTime frame
Expression of BRAF mutation in papillary thyroid carcinoma and expression of RET/PTC rearrangement in Papillary thyroid carcinoma and coexistent thyroiditisTimepoint: Immediately after surgery- candidate genes on live thyroidectomy specimen 1 week post-surgery on formalin fixed paraffin embeded tissues 1 week post-surgery for IHC (immuno-histochemistry markers)—

Secondary

MeasureTime frame
Expression of p63 and CK19 in immunohistochemistry of the surgical thyroid specimenTimepoint: 1 week post-surgery—

Countries

India

Contacts

Public ContactDr Poongkodi Karunakaran

Government Mohan Kumaramangalam Medical College

poongkodithesurgeon@gmail.com9443119743

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 5, 2026