Brain stimulation to reduce craving in alcohol dependent individuals

Efficacy of Prefrontal Cortex Transcranial Direct Current Stimulation on Clinical and Neuropsychological Outcomes in Alcohol Dependence Syndrome: A Double Blind Randomized Shamâ??Controlled Study - PreCoTTA

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/09/027582

Enrollment

225

Registered

2020-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: Transcranial Direct Current Stimulation: The active arms will receive a 2mA current for 20 minutes. The ramp â?? up and ramp â?? down time in the active stimulation would be 30 seconds

Eligibility

Inclusion criteria

Inclusion criteria: a) Patients diagnosed with Alcohol Dependence Syndrome according to ICD-10 Diagnostic Criteria for Research (WHO 1993) b) Male patients aged between 18 â?? 60 years c) Right-handed d) Patients not in active withdrawal as defined by CIWA-Ar score less than 10 e) Patients with at least 5 years of formal education f) Ability to read, write and speak Kannada or Hindi or English

Exclusion criteria

Exclusion criteria: a) Patients fulfilling ICD-10 Diagnostic Criteria for Research (WHO 1993) for other substance dependence syndrome, except nicotine b) History of comorbid other major psychiatric disorder(s) or major medical disorder(s) c) History of epilepsy, significant head injury or any neurosurgical procedure d) Any metallic brain implant or cardiac pacemaker

Design outcomes

Primary

Measure	Time frame
These would include the duration of time to the first drink, cue-induced craving measured on OCDS and the scores on risk taking and impulsivity as measured on the IGT and BART tasks respectively.Timepoint: The data will be collected at 5 time points - baseline, after 10 tDCS sessions, at weeks follow up, at 1 month follow up and at 3 months follow up	—

Secondary

Measure	Time frame
These would include the severity of lapse as measured by the quantity frequency index, scores on other neuropsychological domains and blood biomarker levels of BDNF, leptin and adiponectinTimepoint: The data will be collected at 5 time points - baseline, after 10 tDCS sessions, at weeks follow up, at 1 month follow up and at 3 months follow up	—

Countries

India

Contacts

Public ContactDr Suma Udupa

Kasturba Medical College, Manipal Academy of Higher Education

samir.kp@manipal.edu0820-2922224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026