A clinical trial to study effect of local injection of vitamin D3 on rate of tooth movement in patients undergoing fixed orthodontic treatment.

â?? EVALUATION OF EFFECTIVENESS OF LOCALLY INJECTED CALCITRIOL IN ALTERING RATE OF ORTHODONTIC TOOTH MOVEMENT DURING CANINE RETRACTION â?? RANDOMISED CONTROLLED CLINICAL TRIAL â??

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/09/027568

Enrollment

Registered

2020-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M263- Anomalies of tooth position of fully erupted tooth or teeth

Interventions

Intervention1: locally injectable calcitriol: PDL/ intraligamentary injections of calcitriol is to be given locally into the distal side of canines in patients undergoing fixed orthodontic treatment i

Eligibility

Inclusion criteria

Inclusion criteria: Patients with class I malocclusion with bimaxillary protrusion or class II malocclusion who require bimaxillary 1st premolar extraction. Bimaxillary canine distalisation / retraction

Exclusion criteria

Exclusion criteria: Periodontally compromised patients. No previous history of orthodontic treatment. Subjects with crowded arches. Subjects with parafunctional habits such as bruxism, & unilateral chewing pattern. Subjects with nonvital , endodontically treated teeth, fractured teeth except Ellis class I & class II. History of chronic drug intake.( anti inflammatory drugs, steroids over the prior 3 months.) Medically compromised patients

Design outcomes

Primary

Measure	Time frame
rate of orthodontic tooth movementTimepoint: pre treatment i.e at the initiation of canine distalization post treatment i.e 60 days after 1st intraligamentary (PDL) injection of calcitriol	—

Secondary

Measure	Time frame
Periapical & periradicular reaction( root resorption, bone loss , PDL space, continuity of lamina dura) to locally injected calcitriolTimepoint: Pre treatment i.e at the initiation of canine distalization Mid treatment i.e 60 days after 1st intraligamentary (PDL) injection of calcitriol	—

Countries

India

Contacts

Public ContactDr Shreya Koleshwar

GDCH Mumbai

gopinath73@hotmail.com9821167417

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026