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Effect of prone positioning with HFNC on oxygenation and overall outcomes in severe COVID-19 patients.

Effect of prone positioning and high flow nasal cannula on oxygenation and overall outcome in spontaneously breathing awake patient with COVID-19 induced acute hypoxemic respiratory failure.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/027562
Enrollment
92
Registered
2020-09-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention1: Prone Positioning along with High Flow Nasal Cannula: Effect of Prone Positioning along with High Flow Nasal Cannula on Oxygenation and overall outcomes in biochemical inflammatory mark

Sponsors

Maulana Azad Medical College and Lok Nayak Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with hypoxemic respiratory failure defined as respiratory rate >=20 breaths/min and oxyhemoglobin saturation (SpO2) <94% while receiving supplemental oxygen 6 L/min via nasal cannula or 15 L/min via non-rebreather facemask

Exclusion criteria

Exclusion criteria: 1) Immediate need for intubation (PaO2/FiO2 2) Unstable hemodynamic status 3) Pregnant patients 4) Morbidly obese 5) Patient refusal to PP or any other contraindication to PP

Design outcomes

Primary

MeasureTime frame
The number of patients requiring Non-invasive or invasive mechanical ventilationTimepoint: 1-2weeks—

Secondary

MeasureTime frame
1. Comparison of ABG parameters before PP, end of first proning with HFNC and end of last proning with HFNC 2. Comparison of respiratory rate and SpO2/FiO2 ratio 3. Comparison of biochemical inflammatory markers [Interleukin-6 (IL-6), c- reactive protein (CRP), Neutrophil / Lymphocytes ratio, D-Dimer, pro-calcitonin (PCL), LDH, Serum ferritin] before PP and end of last PP with HFNCTimepoint: 1-2 weeks—

Countries

India

Contacts

Public ContactDr Deepak Kumar

Maulana Azad Medical College and Lok Nayak Hospital

deepakkumar3090@gmail.com9717864257

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026