Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes
Conditions
Interventions
Intervention1: Methylprednisolone pulse therapy: Injection Methylprednisolone 1gm in 100 ml NS intravenously over 30 min once a day x 3 days
Control Intervention1: Normal Saline 100 ml(placebo): Injec
Sponsors
AIIMSNew Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. All consecutive patients with history of acute corrosive ingestion with Zargar endoscopy grade IIb esophageal injury. 2. Age > 18 years 3.Valid consent given by the patient for the study.
Exclusion criteria
Exclusion criteria: 1. Esophageal injury other than endoscopic Zargar grade IIb (Zargar grade I, IIa& III will be excluded). 2. Hemodynamic unstable patient 3. Patients who has received Cardiopulmonary Resuscitation (CPR) 4.Patients who needs Endotracheal intubation and mechanical ventilation 5.Patients who are not conscious 6. History of corrosive ingestion of >24 hours 7.Age 8.Patients who refused to give valid consent for the said study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the efficacy of Methylprednisolone in the prevention of corrosive injury induced esophageal strictureTimepoint: 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare the possible complications like infection, sepsis, stridor, hoarseness, upper gastrointestinal bleed, Acute respiratory distress syndrome, Acute kidney injury, perforation, peritonitis and mediastinitis in both study and control group. 2.We will compare change in blood sugar level, change in blood pressure and electrolyte abnormalities in both intervention and control group. 3.To compare mortality at 8 weeks in both study and control group. Timepoint: During hospital stay till 8 weeks | — |
Countries
India
Contacts
Public ContactDr Irtiqa Sheikh
All India Institute of Medical Sciences,New Delhi
Outcome results
None listed