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To compare the effect of two drugs namely, lignocaine and ephedrine and their combination for pretreatment on pain on injection due to propofol in adult patients undergoing general anaesthesia for elective surgeries

tO COMPARE THE EFFECT OF LIGNOCAINE, EPHEDRINE AND COMBINED LIGNOCAINE AND EPHEDRINE PRETREATMENT ON PAIN ON INJECTION DUE TO PROPOFOL IN ADULT PATIENTS UNDERGOING GENERAL ANAESTHESIA - A ONE YEAR HOSPITAL BASED RANDOMIZED CLINICAL TRIAL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/09/027529
Enrollment
120
Registered
2020-09-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: nil: nil Control Intervention1: Injecting multiple i.v drugs prior to injection of i.v propofol: The drugs used to do so are, i. v Lignocaine, i.v ephedrine and combined i.v lignocai

Sponsors

Dr Rajesh S Mane
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA (American Society of Anaesthesiologists) Grade I and II Age between 18 to 60 years. Patients posted for surgery under General Anaesthesia Informed consent.

Exclusion criteria

Exclusion criteria: History of adverse response to propofol, lignocaine or ephedrine History of allergy, neurologic or cardiovascular disease History of intake of analgesic medication within 24 hours of surgery

Design outcomes

Primary

MeasureTime frame
To compare the effect of lignocaine, ephedrine and combined lignocaine and ephedrine on Pain on injection In patients receiving propofol for General Anaesthesia. Timepoint: at baseline—

Secondary

MeasureTime frame
To compare the effect of lignocaine, ephedrine and combined lignocaine and ephedrine on Systolic Blood Pressure(SBP), Diastolic Blood Pressure(DBP), Mean Arterial Pressure(MAP) and Heart Rate(HR) In patients receiving propofol for General Anaesthesia. Timepoint: at baseline—

Countries

India

Contacts

Public ContactDrRajesh S Mane

J. N. Medical College, Belagavi

drrajeshmane@gmail.com9844131062

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026