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Compare marker abnormalities in COVID positive and negative cancer patients

Comparative evaluation of hematologic and biochemical biomarker abnormalities associated with perioperative management of COVID positive and negative cancer patients: A Pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/09/027518
Enrollment
40
Registered
2020-09-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention1: nil: nil Control Intervention1: nil: nil

Sponsors

Department of anaesthesia AIIMS Rishikesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Cancer patients, Aged 18 to 70 years 2.American Society of Anesthesiologist Grade I-III 3.Patient undergoing oncological surgery.

Exclusion criteria

Exclusion criteria: 1.Any contraindication to general anesthesia 2.Patients with existing acute infection, sepsis. 3.Patients on recent chemotherapy(past 15 days). 4.Patient on chronic treatment with steroids or immune-suppressants. 5.Patient who are morbidly obese, have autoimmune disorders. 6.Patient underwent blood transfusion for 7.Patients not willing to give consent

Design outcomes

Primary

MeasureTime frame
Difference in biochemical and hematological markers (CBC, TLC, ESR, CRP, PCT, Ferritin, D-Dimer , IL-6,IL-10 and TNF alpha) at three time points (preoperatively, immediately and 24hours after the end of the surgery) in COVID positive and negative cancer patients undergoing major oncological surgery.Timepoint: Baseline, Before giving anaesthesia, At end of surgery and 24H after surgery—

Secondary

MeasureTime frame
1. Perioperative adverse events- hypotension, hypoxia, apnea, bradycardia and cardiac arrest. 2. Early mortality- within same hospital admission/within one month, whichever is earlier 3. Major morbidity- Surgical site infection, Need for post-operative ventilation and its duration, need for BIPAP support, Duration of ventilation, inotropic score, ICU stay, length of hospital stay. Timepoint: Baseline, Before giving anaesthesia (T0), At end of surgery (T1) 24H after surgery T(2)—

Countries

India

Contacts

Public ContactBhavna Gupta

AIIMS, Rishikesh

bhavna.kakkar@gmail.com8527686660

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026