A study to look for the changes and effects of normal saline versus isotonic balanced crystalloid on acid base balance and renal functions in patients undergoing intracranial tumour resection

To evaluate effects of normal saline versus isotonic balanced crystalloid on acid base balance and renal functions in patients undergoing intracranial tumour resection

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/09/027507

Enrollment

Registered

2020-09-01

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified

Interventions

Intervention1: To evaluate effects of normal saline versus isotonic balanced crystalloid: To evaluate effects of normal saline versus isotonic balanced crystalloid on acid base balance and renal funct

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex belonging to Americans society of Anaesthesiologists (ASA) class 1 to 2, scheduled to undergo elective surgery for intracranial tumour resection will be enrolled.

Exclusion criteria

Exclusion criteria: Patients having Electrolyte imbalance Preoperative Glasgow Coma Scale (GCS) Hemodynamic instability Pre-existing renal failure (serum creatinine >2) Coagulation abnormalities Pregnancy and Lactation Diabetes mellitus Refusal to give consent will not be included in the study.

Design outcomes

Primary

Measure	Time frame
Acid base status (pH, bicarbonates, base excess) Renal functions [ blood urea, serum creatinine, serum electrolytes, NGAL (Neutrophil gelatinase associated lipocalcin)]Timepoint: Baseline, 1hr after intubation 2hrs after intubation After surgery 4hrs after surgery	—

Secondary

Measure	Time frame
Brain relaxation score Serum osmolality Serum lactate Coagulation profile (PT,PTT , INR)Timepoint: Baseline and 4 hrs after surgery	—

Countries

India

Contacts

Public ContactAkanksha

PANDIT BHAGWAT DAYAL SHARMA. UNIVERSITY OF HEALTH SCIENCES, ROHTAK.

akankshakhatri25@gmail.com8800401471

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026