Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Aspirin: Low dose aspirin (75 mg OD) for 10 days along with standard of care
Control Intervention1: Standard of Care: Standard of care will included standard practice of the institute a
Sponsors
Dr Souvik Maitra
Eligibility
Inclusion criteria
Inclusion criteria: Adult (aged between 18 and 65y) patients with laboratory confirmed SARS- CoV-2 infection with hypoxemia (defined by room air SpO2 <= 94%) at the time of randomization will be included.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate 2. Mechanically ventilated patients 3. Patients with P/F ratio 4. Patients with any known coagulation disorder 5. Patients with known platelet function disorder 6. Patients who are already on antiplatelet therapy 7. Patients with thrombocytopenia (platelet count 8. Patients with any previous intracranial pathology 9. Patients with known gastric/ duodenal ulcer 10. Patients with history of gastro-intestinal bleeding within 3 months 11. Pregnancy women or women who are breastfeeding their children 12. Known allergy to aspirin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare SpO2/ FiO2 ratio in day 1- 7 post randomization in both the groupsTimepoint: day 1- 7 post randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the ventilation free days (VFD. 2. To compare the high flow nasal oxygen and/ or NIV free days (NVFD) in both the groups. 3. To compare supplemental oxygen free days (OFD). 4. To compare mortality in both the groups. Timepoint: 28 day post randomization;5. To compare duration of hospital stay in both the groups. 6. To compare incidence of new onset non- respiratory organ dysfunction (AKI) in both the groups. 7. To compare any adverse effects (major bleeding requiring transfusion, minor bleeding). 8. To compare the incidence of lower limb deep vein thrombosis in both the groups Timepoint: Till hospital discharge/ 28 day | — |
Countries
India
Contacts
Public ContactDr Souvik Maitra
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed