Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: B348- Other viral infections of unspecified site
Conditions
Interventions
Intervention1: Raj Nirwan Bati (RNB capsule): 250 mg twice a day on day 1 and subsequently 125 mg twice a day till 12 days after admission
1. Mercury (Para) 2. Sulphur
(Gandhak) 3. Gold (Sona) 4.
Silv
Sponsors
Uttar Pradesh University of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. RT-PCR confirmed SARS-CoV-2 infected patients. 2. Patients who are symptomatic with severe category of COVID-19 illness including critically ill patients admitted to the dedicated COVID-19 hospital of UPUMS. 3. Patients aged 18 years and above. 4. Patients with history of immergence of clinical symptoms of COVID-19 less than 10 days on the day of admission to the dedicated COVID-19 hospital. 5. The patient or his/her representative providing informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients who are either asymptomatic or having mild or moderate COVID illness. 2. Patients who take medication for less than 4 days after enrolment in the study. 3. Study participants deteriorating by two points on the clinical improvement ordinal scale designed for the study during the course of intervention. 4. Patients with established unresponsive improvement to treatment for co-morbidities. 5. Patients who discontinue the intervention for any reason. 6. Pregnant and lactating females.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvementTimepoint: Assessment will be done at baseline, Day 6, day 12 and Day 18 of admission for Two-point reduction in patientsâ?? clinical status at admission on a six-point ordinal scale, or live discharge from the hospital. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. All-causes of mortality at day 18; 2. Frequency of invasive mechanical ventilation; 3. Duration of oxygen therapy; 4. Duration of hospital admission/stay; and 5. Proportion of patients with improvement in the microbiological, hematological, biochemical and radio-logical parameters.Timepoint: Assessment at baseline, day 6, day 12, and day 18 after admission | — |
Countries
India
Contacts
Public ContactDr Raj Kumar
Uttar Pradesh University of Medical Sciences (UPUMS)
Outcome results
None listed