Health Condition 1: M179- Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention1: Cooled Radiofrequency Genicular Nerve Ablation: In Active group(U) Cooled Radiofrequency Genicular Nerve Ablation will be done under USG(Ultrasound) guided .
Control Intervention1: Cool
Sponsors
Central Hospital Garden Reach South Eastern Railway
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age >= 40 years to 2. Able to understand the informed consent form and provide written informed consent and able to follow up 3. Chronic knee pain for longer than 6 months that interferes with functional activities (for example, ambulation, prolonged standing, etc.) 4. Continued pain in the target knee despite at least 3 months of conservative treatments, including activity modification, home exercise, protective weight bearing, and/or analgesics (for example, acetaminophen or non-steroidal anti-inflammatory drugs [NSAIDs]) 5. Radiologic confirmation of arthritis (x-ray/MRI/CT) of OA grade of 2 (mild), 3 (moderate) or 4 (severe) noted within 6 months for the index knee (Kellgren and Lawrence system)
Exclusion criteria
Exclusion criteria: a. Patient was suffering from advanced systemic disease such as decompensated heart failure, pneumonia, or dementia leaving them too debilitated to participate in follow-up b. Knee had a mechanical injury (e.g., meniscal tear or tendon damage); and/or c. The patient was suffering from a chronic rheumatologic disorder. Evidence of inflammatory arthritis (for example, rheumatoid arthritis) or other systemic inflammatory condition (for example, gout, fibromyalgia) that could cause knee pain d. Evidence of neuropathic pain affecting the index knee e. Previous or pending lower limb amputation f. Hyaluronic acid injection, platelet rich plasma (PRP), stem cell, or arthroscopic debridement/lavage injection into the index knee within 90 days. g. Clinically significant ligamentous laxity of the index knee h. Clinically significant valgus/varus deformities or evidence of pathology (other than osteoarthritis of knee) that materially affects gait or function of the knee or is the underlying cause of the knee pain and/or functional limitations i. Pregnant, nursing or intent on becoming pregnant during the study period j. Allergies to any of the medications to be used during the procedures, including known hypersensitivity (allergy) to hyaluronate preparations or allergies to avian or avian-derived products (including eggs, feathers, or poultry) k. Uncontrolled immunosuppression (e.g. AIDS, cancer, diabetes, etc.) l. Subject currently implanted with pacemaker, stimulator, or defibrillator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare clinical outcomes of genicular nerve cooled radiofrequency ablation (C-RFA) for the treatment of chronic pain due to primary knee osteoarthritis before the procedure(baseline), next day after the procedure, after three-month, after six-month, after twelve-month. 1. By change in pain will be measured in NRS (Numeric Rating Scale). 2. Global subjective improvement in the OKS (Oxford Knee Score) The Oxford Knee Score is determined by a 12-question survey. Timepoint: September 2020 to December 2021 i.e. 16 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Any complications related to the procedures. (weakness, numbness, paraesthesia, neuralgia pseudoaneurysm, others)Timepoint: September 2020 to December 2020 i.e. 4 months.;The Global Perceived Effect (GPE) scale, a quality-of life outcomes instrument, was used to determine subjectsâ?? perceptions of treatment effects from CRFATimepoint: September 2020 to December 2020 i.e. 4 months. | — |
Countries
India
Contacts
Public ContactDr Samir Basak
Central Hospital ,South Eastern Railway
Outcome results
None listed