Health Condition 1: C531- Malignant neoplasm of exocervix
Conditions
Interventions
Intervention1: Image guided intensity modulated radiotherapy and image guided brachytherapy: This will a prospective single arm interventional study. Patients will be treated with whole pelvis Image g
Sponsors
Dr Madhup Rastogi
Eligibility
Inclusion criteria
Inclusion criteria: Age: 18-65 years Informed consent from the patient. KPS score 70 or above. Histopathologically proven Squamous Cell Carcinoma of carcinoma from stage IB2 to IVA (FIGO 2018) Routine hematological, renal and hepatic functions should be with in normal range. No contraindications of MRI. No prior chemotherapy or radiotherapy and surgery
Exclusion criteria
Exclusion criteria: Any histopathology other than squamous cell carcinoma. Patient having any synchronous or metachronous malignancy. Patient having pre-existing renal or cardiovascular disease. Patient hypersensitive to cisplatin. Para-aortic lymph node positive. Patient suffering from uncontrolled HIV, Hep B, Hep C. Pregnant or lactating women. Previous pelvic irradiation. Patient with active inflammatory bowel disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the acute toxicity and to evaluate loco-regional control (LRC) of image guided â??IMRT followed by IGBT in carcinoma cervix patients.Timepoint: 1.LRC will be assessed after 3 months after completion of brachytherapy . 2. Acute toxicity will be assessed weekly during radiation and upto 100 days from start of radiation therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the late toxicity and to evaluate the efficacy in terms of disease free survival (DFS)Timepoint: 1.Late toxicity will be assessed 3 months after completion of radiation upto last date of follow up. 2.DFS will be evaluated from date of registration to first recurrence (local/regional/distant) | — |
Countries
India
Contacts
Public ContactDr Vachaspati Kumar Mishra
Dr RMLIMS Lucknow
Outcome results
None listed