Health Condition 1: I219- Acute myocardial infarction, unspecified
Conditions
Interventions
Intervention1: ARNI(ANGIOTENSION RECEPTOR AND NEPROLYSIN INHIBITOR): 50mg to 200mg
Twice a day
Orally
3 months
Intervention2: Angiotensin receptor neprolysin inhibitor: angiotensin receptor blocker b
Sponsors
aiims hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of spontaneous AMI based on the universal MI definition (2018) -with randomization to occur between 12 hours and 7 days after index MI presentation. 2.EF would calculate using ECHO after index MI presentation and prior to randomization 3.Systolic blood pressure at enrolment would be minimum >=100mmHg irrespective of ongoing beta blocker or ACEI
Exclusion criteria
Exclusion criteria: 1. Cardiogenic shock 2. Coronary artery bypass graft (CABG) 3. Right ventricular MI 4. A known history of angioedema 5. Stroke /transient ischemic attack 6. Bilateral renal artery stenosis 7. Obstructive cardiomyopathy 8. Serum creatinine >2.2 mg/dl 9. Total bilirubin > 3.0 mg/dL) 10. Cirrhosis 11. Previous use of ARNI 12. History of malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in LVEF% (increase in LVEF by 10% from baseline) measured by Simpsonâ??s ruleTimepoint: 15 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Monitoring change in NYHA functional class Monitoring NT pro BNP level in blood Monitoring serum creatinine and potassium level in blood Timepoint: 15 months | — |
Countries
India
Contacts
Public ContactDr Rama Chandra Barik
AIIMS BBSR
Outcome results
None listed