Health Condition 1: C159- Malignant neoplasm of esophagus, unspecified Health Condition 2: C399- Malignant neoplasm of lower respiratory tract, part unspecified Health Condition 3: C383- Malignant neoplasm of mediastinum,part unspecified Health Condition 4: C768- Malignant neoplasm of other specified ill-defined sites Health Condition 5: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung Health Condition 6: C390- Malignant neoplasm of upper respiratory tract, part unspecified
Conditions
Interventions
Intervention1: Desflurane: Patient will be maintained on Desflurane based anaesthesia during the period of One lung ventilation while maintaining the BIS score in the range of 40-60. Fraction of oxyge
Sponsors
Dr BRAIRCH AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age of 18 years or older, but less than 70 years. 2.ASA Status I to III. 3.Patients undergoing surgeries requiring One Lung Ventilation. 4.Agree to participate in the study and have signed written informed consent.
Exclusion criteria
Exclusion criteria: 1.Symptomatic or Severe Obstructive or Restrictive Lung disease. Accepted definition for obstructive disease as defined by the American Thoracic Society and European Respiratory Society Guidelines is FEV1/FVC 2.Requirement of preoperative oxygen support. 3.Preoperative intubation state or under mechanical ventilator support. 4.Baseline arterial pressure of oxygen (Pao2) 5.Symptomatic coronary or peripheral arterial disease 6.Allergic to any drug used during the study. 7.Patients preoperatively on drugs that directly affect Hypoxic pulmonary vasoconstriction (HPV).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial OxygenationTimepoint: 1.on Room air 2.15 minutes after positioning in lateral decubitus on two lung ventilation. 3. every 15 minutes for next 60 monutes on one lung ventilation ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Late effects on cardiac and pulmonary functions between the two agents using CPET and PFTTimepoint: 1.preoperative 2.postoperative 6 week 3.postoperative 12 week ;To compare perioperative complicationsTimepoint: 1.intraoperatively 2.on postoperative day 0 and 1;To evaluate effect on coagulation parametersTimepoint: 1. preoperatively 2. 15 minutes after positioning patient in lateral decubitus position on two lung ventilation 3.termination of OLV;To evaluate Recovery after anaesthesiaTimepoint: on postoperative day 0 and 1 | — |
Countries
India
Contacts
Public ContactDr Sachidanand Jee Bharati
Dr. BRAIRCH AIIMS, New Delhi
Outcome results
None listed