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A PROSPECTIVE RANDOMIZED COMPARATIVE STUDY OF FOUR DIFFERENT ROUTES OF LOCAL ANAESTHETIC AGENT LIGNOCAINE IN ATTENUATION OF BLOOD PRESSURE, HEART RATE AND ECG RESPONSES DURING INSERTION OF LARYNGOSCOPE AND ENDOTRACHEAL TUBE IN CONTROLLED HYPERTENSIVE PATIENTS

A PROSPECTIVE, RANDOMIZED, COMPARATIVE STUDY OF FOUR DIFFERENT ROUTES OF LIGNOCAINE ADMINISTRATION REGARDING ATTENUATION OF HEMODYNAMIC RESPONSES DURING LARYNGOSCOPY AND INTUBATION IN CONTROLLED HYPERTENSIVE PATIENTS.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/08/027365
Enrollment
120
Registered
2020-08-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: INTRAVENOUS LIGNOCAINE ADMINISTRATION REGARDING ATTENUATION OF HEMODYNAMIC RESPONSES DURING LARYNGOSCOPY AND INTUBATION: INTRAVENOUS LIGNOCAINE 1.5 mg/kg PREOPERATIVELY FOR ATTENUATION

Sponsors

OFFICE OF PRINCIPAL MIDNAPORE MEDICAL COLLEGE AND HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age group between 18-65 years of either sex. 2. ASA grade II 3.Elective surgeries requiring laryngoscopy and intubation 4.Posted for general surgery operation.

Exclusion criteria

Exclusion criteria: 1.chance of hemodynamic instability intraoperativel 2. Ischaemic heart disease 3.myocardial infarction 4.any abnormality seen in ECG during preanaesthetic checkup 3. Anticipated difficult intubation. 4. Pregnant patients. 5. Any history of allergy with lignocaine. 6. Any patients below 18 years old and above 65 years old of either sex. 7. intubation time >15 sec/attempt 8.more than 2 attempts at intubation 9.very anxious patients 10.patient unable to communicate. 11.history of substance abuse or concurrent use of nonallopathic medication for any reason 12.chronic opoid use 13.obese patient 13.Basal systolic BP 14.Diabetes 15.severe systemic disorder involving any particular system of respiratory or hepatobiliary or renal etc or in combination. 16.history of CVA 17.past history of heart failure

Design outcomes

Primary

MeasureTime frame
To compare the effect of lignocaine administered through different routes like intravenous or transtracheal or nebulization or gargling regarding attenuating the hemodynamic changes seen after laryngoscopy and endotracheal intubation by means of 1.Blood pressure changes afer direct laryngoscopy 2.Blood pressure changes after endotracheal intubation Timepoint: Observed parameters of primary outcome will be mainly observed at 1 and 3 minute after laryngoscopy and intubation—

Secondary

MeasureTime frame
To compare the effect of lignocaine used by different routes in terms of- 1.Heart rate changes after direct laryngoscopy and intubation. 3.ST segment change after direct laryngoscopy and intubation 5.incidence of post operative sore throat. No long term outcome will be studied in this study as the patients generally do not have regular follow up. Timepoint: In addition to the specific time points for observing primary outcome (1and 3 minute after laryngoscopy and intubation)these parameters of secondary outcome will be observed at 5,15,30,60 and 120 minute after laryngoscopy and intubation and also at the time of extubation. Post operative sore throat will be assessed after 24hour of extubation.—

Countries

India

Contacts

Public ContactDEBALEENA JANA

MIDNAPORE MEDICAL COLLEGE AND HOSPITAL

sumanc24@gmail.com9830234881

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026