Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Hyperbaric Oxygen Therapy: Hyperbaric exposure at 2.5 ATA for 90 minutes in HBO chamber (Monoplace Hyperbaric System, Sigma 36 Elite, Chamber serial number 1209-36)
Control Intervention
Sponsors
Department of Anaesthesiology and Critical Care
Eligibility
Inclusion criteria
Inclusion criteria: Adults (aged 18-70years) of either sex ,admitted in ICU and diagnosed as a case of severe acute pancreatitis, defined as persistent single or multiple organ failure for >48hr based on 2012 revision of Atlanta classification.
Exclusion criteria
Exclusion criteria: 1. Refusal for consent 2. Pregnant patients 3. Any contraindication for Hyperbaric oxygen therapy such as cavitary or current tuberculosis, heart failure, pulmonary edema, acute purulent sinusitis, severe glaucoma, hypercapnic respiratory insufficiency with PCO2 > 60mm Hg, previous rupture of inner earâ??s membrane, sinus bradycardia, inflammation of upper respiratory tract, epilepsy, claustrophobia 4. Patient on mechanical ventilation support
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is to assess the need for mechanical ventilation in patients of Severe Acute Pancreatitis receiving HBO therapyTimepoint: Till patient discharge from ICU or death | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality, change in CRP values, Procalcitonin values, duration of ICU stayTimepoint: Till patient discharge from ICU or death | — |
Countries
India
Contacts
Public ContactDr Samiksha Parashar
Dr.Ram Manohar Lohia Institute of Medical Sciences
Outcome results
None listed