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Lamotrigine vs Pregabalin for postoperative pain relief in Spine Surgeries

A comparison of pregabalin and lamotrigine as pre-emptive analgesia in spine surgery: A randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/08/027307
Enrollment
90
Registered
2020-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S320- Fracture of lumbar vertebra

Interventions

Intervention1: LAMOTRIGINE: Two lamotrigine capsules 100 mg each with a sip of water 1 hour before the expected time of induction of anaesthesia Control Intervention1: PREGABALIN: Two pregabalin capsu

Sponsors

IMS BHU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing spine surgery under general anaesthesia ASA physical status- I / II

Exclusion criteria

Exclusion criteria: ASA III/IV Pregnancy/Lactation Patient with epilepsy Impaired liver functions/renal functions H/O drug abuse/ Alcohol abuse Allergy to pregabalin or lamotrigine H/O vertigo Intake of corticosteroids

Design outcomes

Primary

MeasureTime frame
Visual Analogue Score for PainTimepoint: 1,2,4 and 6 hours—

Secondary

MeasureTime frame
Dosage of analgesia requiredTimepoint: 1,2,4 and 6 hours—

Countries

India

Contacts

Public ContactKavita Meena

Institute of Medical Sciences, BHU

kvtamn68@gmail.com9711897587

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026