Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features Health Condition 2: F331- Major depressive disorder, recurrent, moderate Health Condition 3: F321- Major depressive disorder, singleepisode, moderate Health Condition 4: F322- Major depressive disorder, singleepisode, severe without psychotic features
Conditions
Interventions
Intervention1: Active Priming to Adjunctive rTMS: 6Hz rTMS at 80%RMT over right DLPFC for 10 minutes followed by 100% RMT 1 Hz rTMS over right DLPFC for 21 minutes
Control Intervention1: Sham Priming
Sponsors
King Georges Medical University
Eligibility
Inclusion criteria
Inclusion criteria: Right handed persons Willing to give written informed consent Fulfilling the diagnoses as mentioned according to ICD 10 (F32.1/33.1 and F32.2/F33.2)
Exclusion criteria
Exclusion criteria: Any co morbid alcohol or other substance dependence except for caffeine and nicotine Presence of psychosis History of epilepsy/seizure Comorbidity of severe surgical or medical illnesses not letting the patient cooperate for rTMS Patients with cardiac pacemaker or other metal parts in body Patients who have received ECT in the past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective is to compare the effect of theta priming vis a vis a vis no priming on adjunctive 1 Hz rTMS over right DLPFC in treatment of late life depression. Assessments using HAM D, HAM A, GDS, Somatic symptoms scale 8, HMSE and CGI-I Timepoint: From baseline to end of week 1, 2 and 4 after initiation of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective is to study the associated quantitative EEG changes in frontal beta and theta waves in the two groupsTimepoint: Before, at baseline and after treatment, at the end of 2 weeks | — |
Countries
India
Contacts
Public ContactVidya K L
King Georges Medical University, Lucknow
Outcome results
None listed