Health Condition 1: R578- Other shock
Conditions
Interventions
Intervention1: Noradrenaline: After fluid resuscitation is completed neonates with septic shock will receive noradrenaline as per the randomisation table dose being 0.2 microgram per kg,can be given
Sponsors
Bharati Vidyapeeth hospital
Eligibility
Inclusion criteria
Inclusion criteria: Neonates ( Shock was defined by systemic hypotension (mean blood pressure (i) Tachycardia (heart rate > 20 above baseline ) (ii) Peripheral pulses (iii) Modified extremities colouration (iv) Prolonged capillary refill time >3 sec and; (v) Urine output <1 mL/kg/h
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Response at 1 hour (Resolved/Unresolved) Resolution of shock will be defined at 1 hour as a) Systolic Blood pressure (SBP) as well as Diastolic Blood Pressure (DBP) 5th centile. b) Capillary Refill Time (CFT) 3 s 2. Mortality: Incidence of mortality in both groupsTimepoint: 1 hour for resolution of shock Mortality at discharge from hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Requirement of additional vasopressors.2. Hemodynamic stability requiring no further escalation of vasopressors for a period of ââ?°Â¥ 120 min 3. Vitals (HR, SBP, DBP and MAP) and acid-base parameters 4. Incidence of Complications until discharge i.e. a) Intraventricular Hemorrhage (IVH): b) PVL (Periventricular Leukomalacia) c) Acute Kidney Injury (AKI) d). Necrotizing Enterocolitis (NEC) stage II/ III: e) Duration of days of ventilationTimepoint: Abg at 0 and 60 ââ?¬Ë?mins | — |
Countries
India
Contacts
Public ContactReema A Garegrat
Bharati Vidyapeeth,Pune
Outcome results
None listed