Health Condition 1: G938- Other specified disorders of brain
Conditions
Interventions
Intervention1: Radiotherapy: Planning and treatment
Patients shall be immobilized in the supine position using customised thermoplastic mask for head using appropriate head-rest. Care will be taken d
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 3 years and less than 16 years. Newly diagnosed WNT pathway medulloblastoma. Post-surgery residual disease less than 1.5 cm2 on post-operative MRI brain. No evidence of metastatic disease in the brain, spine or cerebral spinal fluid (CSF) assessed by MRI of the brain/spine and lumbar puncture for CSF cytology. Fit for initiation of adjuvant treatment within 6-weeks of surgery
Exclusion criteria
Exclusion criteria: Age Less than 3 and more than 16 years. Molecular subgroup other than WNT pathway. Post-surgery residual disease more than 1.5cm2 on post-operative imaging. Evidence of any metastatic disease in the brain, spine or CSF. Previous history of radiotherapy or chemotherapy prior to study enrollment. Not fit for initiation of adjuvant treatment within 6 weeks of surgery. Not willing for consent/assent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse-free survival Overall survivalTimepoint: 5 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurocognitive function Endocrine evaluation Hearing status Prognostic factors for survival Timepoint: 5years | — |
Countries
India
Contacts
Public ContactDr Tejpal Gupta
Tata Memorial Hospital
Outcome results
None listed