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Comparison of outcomes of a two drug versus a single drug regimen in women undergoing IVF

Comparison of Dual versus Single trigger in Antagonist cycles in non donor In Vitro Fertilization : A Randomised Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/08/027030
Enrollment
160
Registered
2020-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N978- Female infertility of other origin Health Condition 2: N971- Female infertility of tubal origin Health Condition 3: N979- Female infertility, unspecified

Interventions

Intervention1: Dual Trigger: Injection Leuprolide 1 mg given subcutaneously along with injection Recombinant Human Chorionic Gonadotropin (r-hCG) 250mcg given subcutaneously, single dose each. Cont

Sponsors

Dr Aryan Kashyap
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients willing to participate 2 Age - 21 to 38 years (both included) 3 Tubal factor infertility 4 Male factor infertility 5 Unexplained infertility 6 Normal ovarian reserve â?? A baseline Antral follicle count between 5-15(both of which are included)

Exclusion criteria

Exclusion criteria: 1 Patients with Polycystic Ovarian syndrome 2 Patients with Endocrine disorders â?? Diabetes Mellitus, uncorrected hypothyroidism, Hyperprolactinemia, congenital adrenal hyperplasia • Patients with Thin endometrium ( • Previous History of uterine surgeries, adhesiolysis, myomectomy and adenomyosis • Poor Ovarian reserve (AFC

Design outcomes

Primary

MeasureTime frame
1.Number of Metaphase II oocytes retrieved 2.Number of good quality embryos Timepoint: 1. At time of Oocyte retreival 2. At time of Embryo transfer

Secondary

MeasureTime frame
1. Determination of Luteinizing hormone levels twelve hours post trigger 2. Implantation rates in both the group 3. Number of embryos frozen Timepoint: 1.12 hours after trigger administration 2. 14 days after Embryo transfer 3. AT time of embryo transfer

Countries

India

Contacts

Public ContactDr Aryan Kashyap

All India Institute of Medical Sciences, New Delhi

drneetasingh@yahoo.com9818506855

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 12, 2026