Health Condition 1: K70- Alcoholic liver disease Health Condition 2: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Nutritional Therapy: 30-35kcal/kg/day, 1-1.5gm/kg/day protein for 6 months
Control Intervention1: No nutritional therapy: Normal diet
Sponsors
Deptt of Gastroenterology
Eligibility
Inclusion criteria
Inclusion criteria: Liver cirrhosis (Child B or Child C class) Age between 18-60 years History of recovery from episode of overt hepatic encephalopathy (West-Haven grade 1 and above) in last 12 months
Exclusion criteria
Exclusion criteria: Evidence of overt hepatic encephalopathy at the time of enrollment History of taking lactulose, rifaximin, neomycin, metronidazole, L-Ornithine L-Aspartate or probiotics in past 7 days. Alcohol intake during past 6 weeks. Receiving secondary prophylaxis for Spontaneous Bacterial Peritonitis. Previous transjugular intrahepatic portosystemic shunts or shunt surgery. Significant comorbid illness such as heart, respiratory or kidney failure,and neurological disease such as Alzheimerâ??s disease, Parkinsonâ??s disease and non hepatic Metabolic Encephalopathies. Receiving psychoactive drugs, promotility and hypomotility drugs Hepatocellular carcinoma Electrolyte abnormality (Serum sodium Intercurrent infection such as spontaneous bacterial peritonitis Patients of acute on chronic liver failure (ACLF).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time taken for first breakthrough episode of Overt Hepatic EncephalopathyTimepoint: 0, 1month, 2 month, 3 month, 4 month, 5 month, 6 month | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in Health related Quality of Life (HRQOL). Improvement in Anthropometry Parameters (mid arm circumference, triceps skin fold thickness, hand grip, skeletal muscle mass, body fat mass, percent body fat) Changes in serum cytokines (IL-1,6,10,18,TNF,Endotoxins) level at 6 months. Correlation of baseline arterial Ammonia levels, Psychometric test score, Critical Flicker Frequency values, Childâ??s score, MELD score with recurrence of Overt Hepatic Encephalopathy Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr Hardik Ahuja
GB Pant Institute of Post graduate Medical Education and Research
Outcome results
None listed