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Is endoscopic therapy with oral medicine better than endoscopic therapy alone to prevent further episodes of hemetemesis (blood in vomitus) in children with portal hypertension

Endoscopic variceal ligation alone or in combination with non-selective beta blocker for secondary prophylaxis in children with portal hypertension- A randomised control trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/08/026982
Enrollment
50
Registered
2020-08-04
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K766- Portal hypertension

Interventions

Intervention1: Endoscopic band ligation plus non selective beta blocker: All children included in this arm of the study will undergo endoscopic band ligation along with use of non selective beta block

Sponsors

Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All children of age 3-18 years with portal hypertension with a prior history of oesophageal variceal bleed

Exclusion criteria

Exclusion criteria: Previously underwent endoscopic band ligation or sclerotherapy Large gastric varix (F3 varix) Contraindications to the use of beta blockers Previous shunt surgery

Design outcomes

Primary

MeasureTime frame
Rate of rebleeding in children with portal hypertension receiving secondary prophylaxis with EVL alone versus EVL with beta blockersTimepoint: Early: Rebleeding occurring before variceal eradication. Late: Rebleeding occurring after variceal eradication till 1 year of follow up.—

Secondary

MeasureTime frame
Compliance with beta blockersTimepoint: Till 1 year;Percentage of children developing complications due to EVL or beta blockersTimepoint: Till 1 year—

Countries

India

Contacts

Public ContactDr Srinivas Srinidhi Vadlapudi

Sanjay Gandhi Postgraduate Institute of medical Sciences

srinivas.vadlapudi19@gmail.com9652521524

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026